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doi: 10.1111/jgs.15966

The National Cancer Institute warns that "too many enemas of any kind can cause changes in normal blood chemistry, chemicals that occur naturally in the body and keep the muscles, heart, and other organs working properly." Some experts specifically warn against using coffee as the stimulant in an enema, citing a lack of research on its potential effects

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The formula is most often used in weight management and cutting programs, where training intensity, performance, and the use of fats as an energy source are important

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