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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

This article contains a description of these processes along with various useful charts

They criticized the CMS methodology as relying too heavily on time and not enough on the overall intensity, which is higher on account of greater expectations for restoring normal anatomical relationships