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8 Analysis of disease-associated variants of SLC33A1

In clinical practice, several drugs are used for CIPN, such as pregabalin, tricyclic antidepressants, and serotonin-noradrenaline reuptake inhibitors

Therefore, further research on the intrinsic link between acetaldehyde and epigenetic modifications is imperative to identify corresponding targets that can reduce the damage caused by acetaldehyde to the body

Recent indications that calcium overload enhances PTP opening by peroxynitrite suggest that calcium-dependent sensitization of certain mitochondrial proteins to oxidative/nitrative damage is critical for apoptosis to proceed following peroxynitrite exposure (142)

139) (Note: LCPs are long-chain polyunsaturated fatty acids: omega-6 (from canola, olive, safflower, and corn oils) and omega-3 (from flaxseed oil and fish oil)) Allergies frequently disrupt fatty acid metabolism. (p