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1 Institute of Biochemistry, Charit University Medicine Berlin, Berlin, Germany 2 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong 3 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 4 Neuro-Degeneration and -Development and Repair, Institute of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Embryo development relies on the complex interplay of the basic cellular processes including proliferation, differentiation, and apoptotic cell death

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