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Unfortunately, the data may not be conclusive, as the research on murine models with disabled lipolytic receptors suggested that the peptide still led to apparent weight loss, suggesting its actions might not solely rely on these receptors

Chemosphere 254:126792

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Consistently, another study demonstrated that abnormal PKM2/PKM1 alternative splicing results in enhanced PKM1 and diminished PKM2 mRNA expression, attenuates decidualization, and may contributed to repeated implantation failure (41) ( Figure 1 )