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The clinical trial protocol explicitly allowed for delayed escalation based on tolerability

Magnesium supplementation substantially reversed the resistance to vitamin D treatment (de Baaij, Hoenderop, and Bindels 2015

Consider alternative therapies, if available

Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy

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For example, the adjective depressed is lemmatized to depressed, but it is not aggregated with the noun depression, as the lemma is different and retains its meaning as a separate concept