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The non-structural protein 1 (NS1) of IAV suppresses interferon signaling by blocking the activation of retinoic acid-inducible gene I (RIG-I) and interferon regulatory factor 3 (IRF3) (9), while PB2 interferes with the function of mitochondrial antiviral signaling protein (MAVS) to inhibit type I interferon expression (10)

The NF-B pathway functions as a central pro-survival and pro-inflammatory transcription factor that promotes tumor progression by suppressing tumor suppressors such as phosphatase and tensin homolog (PTEN), thereby indirectly enhancing PI3K/AKT signaling and supporting cancer cell viability

Liu H, Guo H, Jian Z et al (2020b) Copper induces oxidative stress and apoptosis in the mouse liver

Lothstein and Gause, ) and a decrease in pro-inflammatory cytokines such as IFN and TNF (Smallwood et al .,

doi: 10.1021/jf000004n

In NP, the key steps of screening potential drugs involve the construction and analysis of drug-target networks