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Perturbation of the 1-carbon cycle result in folate deficiency and abnormal plasma Hcy concentrations [104, 105], which may contribute to the risk that any given mother will or will not have a child with DS

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Lowered cellular redox status increases susceptibility to oxidative stress that may lead to cell death and virus release (Raftos et al., 2007

Choosing the right treatment depends on absorption, severity of deficiency, lifestyle, and underlying medical conditions

Translational epidemiology moves beyond accuracy to ask whether innovations improve hard outcomes at acceptable cost, across diverse care levels