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Siebeneicher, H

On top of its important role as the powerhouse of the cell, these organelles are also essential regulators of cellular metabolism, redox state, intracellular calcium signaling, and programmed cell death mechanisms [12,13,14,15]

While peroxidases were known at the time, and their possible involvement in ascorbate oxidation previously noted (Mapson and Goddard 1951), the physiological functions of such enzymes were considered to be as much in H 2 O 2 -dependent oxidations as reductant-dependent H 2 O 2 removal