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Efficacy of therapeutic plasma exchange for treatment of stiff-person syndrome

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At the mechanistic level, PRR specifically binds to the cysteine-rich region at the C-terminus of DPP4, increasing the level of dipeptidyl peptidase 4 (DPP4) protein, which in turn activates the JNK signaling pathway while inhibiting SIRT3 and fibroblast growth factor receptor 1 (FGFR1) signals, leading to the death of pyroptotic cells (Xie S