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Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al

This elevation in cytokine levels was linked to neural inflammation and subsequent memory impairments

The formulation was optimized by a Box-Behnken design, which analyzed the effects of three independent variables, viz

They found that DDD therapeutically targets AS by enhancing mitochondrial function through the HIF-1 signaling pathway, reducing ROS levels, and modulating GPX4, Bcl2, and Bax protein levels, thereby benefiting AS and hyperlipidemia (Wu et al., 2023a)

It may seem contradictory that both diarrhoea and constipation appear on the side effect list, but this reflects the variability in individual responses to slowed gastric emptying