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Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression

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Because the anagen follicle is metabolically demanding and richly vascularized, improved perifollicular microcirculation is a plausible contributor to a healthier growth phase

Roth et al., 2000), disrupt steroid hormone synthesis, and suppresses estrus behavior (Kadokawa et al., 2012

175 Notably, lactate-mediated modifications, specifically P53K120la and K139la, have been shown to weaken the ability of p53 to bind DNA and undergo liquidliquid phase separation (LLPS), thereby diminishing its tumor-suppressive function both in vitro and in vivo