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2004) have shown to decrease AUC of mycophenolic acid (immunosuppressive) when patient had either or both polymorphisms (Kuypers et al., 2005) Non-carriers of the T-275A and C-2152T 1A9 promoter polymorphisms (low 1A9 expressors) showed a trend toward increased gastrointestinal toxicity of mycophenolic acid

Tieliu Shi, [email protected] This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These safety concerns underscore the need for controlled, titratable delivery systems and thorough immunomonitoring in future trials

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