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The biochemical interactions between transplanted cells and recipient cells are crucial, and elucidating the signaling pathways involved is both a challenging and critical task

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Free Radical Biology & Medicine 122, 13

Upon exposure to TAM, it demonstrated a strong affinity for liver tissue, where it is converted into 4-hydroxytamoxifen, an active metabolite that induces structural changes in cell membranes and modified cell membrane permeability