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The oxygen free radicals oxidize the lipid because the granulocytes and macrophages produce an excess amount of O 2 , H 2 O 2 during the phagocytosis

NAD+ contributes to skin health indirectly through its anti-aging effects, supporting DNA repair and mitochondrial function, which can slow visible signs of aging over time

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Frederico RCP1 (1) Pontifcia Universidade Catlica do Paran, Londrina, PR, Brasil Diabetology & Metabolic Syndrome 2026: PO279 Introduction: Abdominal obesity is considered a key marker of cardiometabolic risk, being associated with increased insulin resistance, endothelial dysfunction, and systemic inflammation

Results SIRT3 suppresses HSC response to classic trained immunity, acute inflammation and tissue functional decline To determine whether SIRT3 regulates HSC response to classic trained immunity induction, we crossed Cre-inducible Sirt3 -overexpressing mice with Mx1-Cre mice to generate mice that overexpress SIRT3 in the hematopoietic system (Mx1-T3) (Extended Data Fig