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Nakajima and Van Houten, 2013)

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While the molecular ruthenium catalyst and the nanoreactors without carbon fluorinated moieties were cytotoxic in the low micromolar range in a 21% O 2 atmosphere, these compounds lost their therapeutic effect in a 1% O 2 atmosphere

Importantly, the non-oxidative phase does not produce NADPH

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GSSP can form either by direct reaction with reactive oxygen species (ROS) or by reaction with secondary products of oxidative stress such as GSSG (Dalle-Donne et al