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The inhibitory effect of mTORC1 on autophagy is induced by phosphorylating and suppressing the nuclear translocation of transcription factor EB (TFEB) 70

In line with this concept, we and others showed that reductive stress perturbs protein disulfide formation leading to ER stress in yeast and intracellular retention of membrane proteins in human cells (32, 60, 100, 113)

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Further comparison with micafungin or posaconazole suggests an advantage for rezafungin with higher survival rate compared to micafungin or posaconazole at their respective human AUC equivalent doses (Figure 1)