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Combining with Other Ingredients (Retinoids, Acids) Although copper peptides promote repair and collagen synthesis, avoid simultaneous use with highly irritating ingredients: Retinoids (Vitamin A derivatives): Can accelerate exfoliation and may react with copper ions, increasing irritation

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Native amylin peptides are prone to aggregation and relatively rapid degradation under certain laboratory conditions

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However, human safety data remains limited to anecdotal reports and Phase I/II trial abstracts that never reached full peer-reviewed publication