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Second, the tissue-specific differences in FA metabolism, where FA metabolism in various organs, such as the liver and kidneys, influences distinct stages of GA progression, and the varying tissue affinities exhibited by drugs, such as the PPAR agonists pioglitazone (113) and aleglitazar (240), exhibit stronger affinity for the hepatic tissue, redistributing visceral fat to peripheral tissues

( D ) HEK293T cells were transfected with either SFB vector or SFB-PTPN22

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