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Acknowledgements This work was supported by the National Natural Science Foundation of China (82073313 to D.L.), the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province (GZY-KJS-SD-2023-094), the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital (2023ZYZX02) and the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project (to D.L.)

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However, in male mice, 1,000 mg/kg SG caused a significant increase in WBC, which is attributed to the increase in GRA counts ( p 2000 mg/kg

Due to differences in the bioavailability of oral versus injectable formulations, further phase 3 trial evidence is needed to establish both efficacy and safety