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In this study, we have assessed disulfirams effects on neuroblastoma using in vitro and in vivo models, focusing on how it modulates the neuroblast transcriptome and epigenome, particularly via MYCN and KAT2A

Oral MTX responsiveness can be enhanced by administering a large starting dose and rapidly titrating the medication

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Taken together, there is no doubt that measurement of endothelial function provides substantial prognostic information about future cardiovascular events in atherosclerotic disease and hypertension, whereas its role in primary prevention and whether the introduction of novel methods to assess endothelial function will further increase its prognostic potential 52 remains to be established

Moreover, the Pasteur had applied for a US patent on blood tests for LAV four months earlier than Gallo