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Landmark trials, including the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) and Irbesartan Diabetic Nephropathy Trial (IDNT) studies, demonstrated that ARBs reduce progression to end-stage kidney disease (ESKD) in type 2 diabetes mellitus (T2DM) patients with proteinuria (112)

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The Fire That Never Goes Out (Chronic Neuroinflammation) Microglia, the brain's immune cells, shift to a pro-inflammatory M1 phenotype to clear debris