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Guo X, Jiang Q, Tuccitto A, Chan D, Alqawlaq S, Won G-J et al (2018b) The AMPK-PGC-1 signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury

Among the known PTMs, Ser46 is another major phosphorylation site of the transactivation domain (Liebl and Hofmann, 2019)

This leads to their clustering and activation, which also induces a conformational change [42,43]

Bai Y, Zhao Y, Li Y, Xu J, Fu X, Gao X, et al

Finally, the study of oxidative stress in lung, liver and kidney fibrosis can provide insights into the involvement of ROS/RNS in the pathogenesis of excessive extracellular matrix deposition in different compatments and may lead to the development of novel treatments potentially transferable to the therapy of scleroderma patients

Some of this work was performed at the Simons Electron Microscopy Center and National Resource for Automated Molecular Microscopy located at the New York Structural Biology Center, supported by grants from the Simons Foundation (SF349247), NYSTAR, the Agouron Institute (F00316), and the NIH (GM103310, OD019994)