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In particular, we aimed to assess the role of inflammation and oxidative stress with a focus on the nuclear factor-kappa B (NF-B), the Janus kinase/signal transducer and activator of the transcription3 (JAK/STAT3), nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), peroxisome proliferator-activated receptor-gamma (PPAR-), and silent information regulator-1 (SIRT1) in pathogenesis of intestinal injury induced by MTX

L.VisserE

These may include redness, swelling, and pain at the injection site

10.1073/pnas.96.11.6161 3 AtkinsonD

In addition, the degree of immune cell infiltration in the tumor microenvironment affects the efficacy of glutamine-targeted therapy

doi: 10.3389/fendo.2014.00056 Received 20 March 2014 Accepted 07 April 2014 Published 22 April 2014 Volume 5 - 2014 Edited by Rosaria Meccariello, University of Naples Parthenope, Italy Reviewed by Rosanna Chianese, Second University of Naples, Italy