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found that diltiazem can be metabolized by Bacteroides thetaiotaomicron ( Bacteroides dorei in the gut microbiota of spontaneously hypertensive rat (SHR) was negatively correlated with the maximum concentration and elimination half-life of nifedipine, suggesting that Bacteroides dorei may possess enzyme activity capable of directly metabolizing nifedipine

Beyond conventional antifungal combinations, a host defense peptide mimetic has emerged as promising enhancers of existing antifungal agents

There are knockout mouse lines, including Spi1 tm1Ram (McKercher et al (1996) EMBO J.15: 5647- tm2b(EUCOMM)Wtsi (International Knockout Mouse Consortium) and Spi1 tm2.1DgtHuman SPI1 (Iwasaki et al (2005) Blood 106: 1590-

DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

In the FA-AKI model, FA-induced ferroptosis exacerbated renal injury by triggering inflammation to induce other types of cell death, consistent with the increase in the expression of TWEAK and Fn14 in renal tubular epithelial cells in the AKI context [164,165,166]

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