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used QUE and 5-FU to construct chitosan nanoparticles, which induced apoptosis and cell cycle arrest at the G0/G1 phase in HCT116 CRC cells by activating the p53/p21 axis (31)

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Hansel B, Giral P, Nobecourt E, Chantepie S, Bruckert E, Chapman MJ, Kontush A