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In fact, pernicious means gradual harm. However, pernicious anaemia is easily treated with vitamin B12 supplements

Individual researchers rarely have access to HPLC verification, which is why strict cold-chain adherence is non-negotiable

More specialised tests such as active B12 (holotranscobalamin) or methylmalonic acid may be available through specialist referral, though availability varies across the UK

An under-dosed product will never achieve the target plasma concentration, making any half-life calculation irrelevant

Raloxifene is a new SERM developed for osteoporosis that appears to prevent breast cancer (Lewis and Jordan, 2005)

But it does need proper treatment