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Superoxide radicals (O 2 ), a type of ROS generated during metabolic processes, are converted into H 2 O 2 and O 2 by SOD, using metal as a cofactor (187)

Total DNA was extracted with Genomic DNA Isolation Kit (Norgen Biotek Corp., Thorold, Ontario, Canada), according to the manufacturers protocol

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The orbitofrontal cortex shares connections with limbic system, amygdala (extensive reciprocal connections), and direct and indirect connections with the hypothalamus