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Preclinical Research Findings The published 5-amino-1MQ dataset comes primarily from mouse models of diet-induced obesity: In vitro studies demonstrated NNMT inhibition in differentiated adipocytes, with reduced 1-methylnicotinamide and increased NAD+ at micromolar concentrations

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On March 2, 2023, the histotripsy IDE clinical study was re-designated as a Category B (Non-experimental/Investigational) IDE study