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One prime example is the discovery of the nutrient sensing mechanism for cholesterol, which led to the development of life-saving statin drugs (and the Nobel Prize)

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doi: 10.1016/j.ocarto.2024.100533 103 JainAGyoriBMHakimSJainASunLPetrovaVet al

The role of NF-B is complex and context-dependent, and it can be considered beneficial or detrimental (Albensi, 2019)

meningitidis (Pericone et al., 2000

Brain Res 618:181189 Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R (2006) The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes