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Lacroix J, Hebert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, et al

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Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M

Prevalence and progression of NPS in AD patients Apathy, depression, anxiety, and agitation/aggression manifest early in AD, while hallucination and delusion generally occur at a later stage, often worsening as the disease progresses

revealed that lactate serves as a precursor for a novel post-translational modification (PTM): lysine lactylation (Kla) ( Immunotherapy, especially immune checkpoint blockade, has revolutionized cancer treatment, but its efficacy is often limited by primary or acquired resistance