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While H 2 O 2 did not directly contribute to polyamine-induced cell death under our experimental conditions, polyamines have previously been shown to enhance cellular sensitivity to RSL3-induced ferroptosis through H 2 O 2 generation 46

Effects of flavonoids on immune and inflammatory cell functions

When your body is better able to eliminate harmful substances, your skin often appears clearer and more radiant

38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

In a normal or resting state, Nrf2 molecules are tightly bound in the cytoplasm by Keap-1, rendering them inactive

Glutathione is a powerful antioxidant that helps reduce inflammation, supports detoxification, and strengthens the immune system