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For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at MICROBIOLOGY: Enrofloxacin is bactericidal and exerts its antibacterial effect by inhibiting bacterial DNA gyrase (a type II topoisomerase) thereby preventing DNA supercoiling and replication which leads to cell death.1 Enrofloxacin is active against Gram-negative and Gram-positive bacteria