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How ROS causes this proliferative effect is best addressed by examining the cellular protective mechanisms that deal with ROS, returning focus to GSH and thiol regulatory pathways

The abundance of each mass isotopomer was then mathematically corrected to eliminate natural abundance isotopes and normalized to the protein content of each sample

10.1016/j.parkreldis.2016.03.012 136 FlowersS

Glutathione and immune function

It is accepted that an excessive burden of ROS may lead to abnormal cell growth, corresponding changes in intracellular homeostasis and damage to important components of in the cell when the antioxidant defense and/or DNA repair mechanisms cannot balance the excess oxidants [29]

Cancer Chemother Pharmacol 65 , 437446, doi:10.1007/s00280-009-1046-1 (2010)