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D.et al (2020)

CDK4/6 inhibitor treatment for patients with hormone receptor-positive, HER2negative, advanced or metastatic breast cancer: a US food and drug administration pooled analysis

10.1371/journal.pone.0052989 95

The animal study was approved by Animal Ethics Committee of Capital Medical University

Kinney, H

Based upon the data in the study, we propose that CVS is likely the result of cellular hyperexcitability, as a result of a vicious cycle of elevated intracellular cations and mitochondrial dysfunction (Figure 1)