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Consistent with the in vitro results above, transfer of Lip-1 ex vivotreated 2C CD8 + T cells significantly inhibited tumor growth in B16-SIYbearing mice (Supplemental Figure 2, AC) accompanied by an increased accumulation and effector function of transferred CD8 + T cells within tumors (Supplemental Figure 2, DH)

doi:10.1007/s13555-020-00461-0

The y-peptide bond is important for not being degraded by most peptidases in the cell, with the exception of GGTs (gamma-glutamyl transferase) (Ohkama-Ohtsu et al

M-QTLs not meeting these criteria may still contribute to Fe tolerance in a trait- or context-specific manner

Cytc then binds to other apoptotic proteins, such as apoptosis-inducing factor, to form complexes that activate caspases, including caspase-9, initiating a caspase cascade