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M: macrophages MUC2: mucin-2 MUC6: mucin-6 MyD88: myeloid differentiation primary response protein 88 NADH : nicotinamide adenine dinucleotide NF-B: nuclear factor kappa-B NLRP3: nucleotide- binding oligomerization domain, leucine- rich repeat and pyrin domain- containing 3 NOX1: NADPH oxidases 1 NPHM: natural plant-derived herbal medicine NQO1: NAD(P)H: quinone oxidoreductase 1 Nrf2: nuclear respiratory factor 2 NSAIDs: nonsteroidal antiinflammatory drugs

582 In short, the treatment of AD is still an important clinical problem, targeting the key pathway of ferroptosis for treating AD may be a breakthrough