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Current studies suggest that the pathophysiological mechanisms of EDC involve multiple factors, including chronic inflammation, neurotransmitter imbalance, hypothalamicpituitaryadrenal (HPA) axis dysfunction, and impaired synaptic plasticity (Yan et al., 2025)

Hyperbaric oxygen and hyperbaric air treatment result in comparable neuronal death reduction and improved behavioral outcome after transient forebrain ischemia in the gerbil

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In this model, CRTC1 was identified as a direct target of miR-184-3p, suggesting that the loss of this miRNA compromises molecular mechanisms essential for HPA axis homeostasis and affective behavior regulation (Xu et al., 2024)

Cancer Res 49, 3985989

GABA binds to two different classes of receptors, the fast-acting ligand gated or ionotropic receptor GABA A and GABA B