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Tobacco smoke is the major cause of lung cancer and several other lung diseases, such as emphysema - a disorder where the air sacs in the lungs become enlarged and damaged reducing the surface area for the exchange of oxygen and carbon dioxide.

[26] In the 17th century, 75% of all colonists in Virginia had come as servants, [27] indentured (with a term of 4 to 7 years of service) or Africans in perpetuity (for life), the latter being preferred as they were cheaper sources of labor: If it were not for the accidental negroes [brought by Treasurer ], I were not able to raise one pound of tobacco this year for the defrayment of any public work.These slaves are the most proper and cheap instruments for this plantation that can be

Consequently, it is difficult to make generalizations about efficacy for cessation based on clinical trials involving a particular e-cigarette, and there is presently inadequate evidence to conclude that e-cigarettes, in general, increase smoking cessation