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doi: 10.1084/jem.175.4.1111 229 LiuCHLiuHGeB

doi: 10.1074/jbc.M114.567685 17 ChenY.LiuY.LanT.QinW.ZhuY.QinK.et al

By modulating the translocation of the RXR binding partner (orphan nuclear receptor Nur77), from the nucleus to the mitochondria it inhibits cell growth and induces apoptosis ( Insulin-Like Growth Factor and Endocrine-Related Cancer Many studies have demonstrated that in the absence of IGF-1 there is an impairment of gonadal steroidogenesis (Figure 3 there are many levels of crosstalk between the hypothalamic pituitary GH and IGF-1 axis, and endocrine organs