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Summary of the AOP Events: Molecular Initiating Events (MIE) Key Events (KE) Adverse Outcomes (AO) Relationships Between Two Key Events (Including MIEs and AOs) Network View Prototypical Stressors Life Stage Applicability Taxonomic Applicability Sex Applicability Overall Assessment of the AOP Biological plausibility, empirical support and quantitative understanding of the KERs and the evidence that uphold essentialities of KEs in this AOP were analyzed together for the overall assessment of an AOP

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Within the ER (endoplasmic reticulum), there are processes that check to make sure that proteins are made and folded correctly
The vitamin B 12 is an important cofactor for many enzymes (Scott et al., 1964)