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In plain terms: it targets a root cause of stubborn fat at the cellular level the metabolic brake instead of just turning up the effort you're already putting in

MATERIALS and METHODS 2.1

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A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis

Robert Cox and Sam Jacob of the Histopathology Research Laboratory at Shriners Hospital for Children, Galveston for their support in histological processing and light microscopic analysis of the EWAT tissue samples (grant #84060, PI: Dr