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As a proof of concept, we tested this signature in previously published bulk RNA-sequencing (RNA-seq) data from in vitro OSKM reprogramming 40 , and found it was significantly enriched in iPS cells as compared to the mouse embryonic fibroblasts (MEFs) from which the iPS cells were derived (Extended Data Fig

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In a study by Ge et al., AGEs of bovine serum albumin (AGE-BSA) stimulated the maturation of human DCs and increased their ability to activate T cells (204)

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Gene regulation by small interfering RNA (siRNA) The RNAi pathway can be activated by the entry of a transgene that provides long dsRNA or a virus