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Increased sensitivity to both glutamine deprivation and GLS inhibition suggests that UPS and highly GLS + STS subtypes depend on glutamine-derived glutamate for energetic and biosynthetic demands rather than redox homoeostasis and antioxidant production, which may be achieved through additional mechanisms

Drug discovery and development for neglected diseases: the DNDi model

Melatonin has been widely investigated for its anti-proliferative and anti-apoptotic properties on cancer cells, revealing its oncostatic effects

S4E), further emphasizing that GSH depletion is a key regulator of mitophagy in PTDSS1-deficient cells

The preferred prevention strategy against cataracts is the maintenance of the antioxidant levels in the lens