Key Points More than 100 genetic loci have been associated with ankylosing spondylitis (AS), but together they explain less than 30% of AS heritability Multiple genes involved in antigen processing and presentation are associated with AS Investigation into the cellular sources and regulation of IL-17 production is crucial to understanding the pathogenesis of AS Cells involved in type 3 immunity produce IL-17 and include innate lymphoid cells and T cells Given the efficacy of the anti-IL-17 monoclonal antibody secukinumab in the treatment of AS, other therapies targeting type 3 immunity could also be effective Abstract Over the past 5 years, advances in high-throughput techniques and studies involving large cohorts of patients have led to considerable advances in the identification of novel genetic associations and immune pathways involved in ankylosing spondylitis (AS)
Annals Romanian Soc Cell Biology
Change history 24 January 2025 A Correction to this paper has been published: Abbreviations GC: Gastric cancer MT1G: Metallothionein-1G GPX4: Phospholipid hydroperoxide glutathione peroxidase SLC7A11: Cystine/glutamate transporter FSP1: Ferroptosis suppressor protein 1 DHODH: Dihydroorotate dehydrogenase (quinone) SQSTM1: Sequestosome - 1 LC3B: Recombinant Human Microtubule - Associated Protein 1 Light Chain 3 Beta ARNTL: Basic helix-loop-helix ARNT-like protein 1 EGLN2: Egl nine homolog 2 RSL3: (1S,3R)-RSL3 Fer-1: Ferrostatin-1 DFOM: Deferoxamine mesylate MDA: Malondialdehyde SOD: Superoxide dismutase GSH: Reduced glutathione Co-IP: Co-immunoprecipitation ROS: Reactive oxygen species RTqPCR: Real-time quantitative polymerase chain reaction TEM: Transmission electron microscope References Smyth, E
That means there are no standardized, official dosing guidelines for obesity outcomes, and products sold in the market may not meet pharmaceutical-level quality controls
Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1
All authors participated in data collection, discussion of the manuscript and provided critical revisions, and approved the final version of the manuscript for submission
