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Vitamin D active ligand (1,25-dihydroxyvitamin D3 or calcitriol) normally binds to the VDR nuclear receptor, forming a heterodimer with the Retinoid X Receptor (RXR), which interacts with vitamin D response elements (VDREs) to regulate gene transcription ( It has been shown that high levels of vitamin D are associated with a lower risk of many cancer types (63)

Structure, Function, Aging and Turnover of Aggrecan in the Intervertebral Disc

10.1016/j.jsbmb.2017.05.006 110 FukudaY.TeragawaH.MatsudaK.YamagataT.MatsuuraH.ChayamaK

REFCK2 samples, and 13 upregulated and 46 downregulated genes in the REFCK1 vs

Meta-analyses indicate that endoscopic ultrasound (EUS)-guided fine-needle aspiration or biopsy offers higher accuracy for cytological and histological diagnosis compared to an endoscopic retrograde cholangiopancreatography (ERCP)-based approach 34,35,36,37 , and single-operator cholangioscopy 38 or peroral cholangioscopy 39,40 may also be helpful for the identification of malignant strictures and to guide targeted intraductal biopsies, alone or in combination with other procedures

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