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MK-677 is a ghrelin mimetic that stimulates the bodys own production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) without suppressing natural testosterone or raising cortisol

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IGF-1 serves as the primary mediator of many growth hormone effects throughout the body

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It is also one of the strongest arguments for the combination approach, where sermorelin helps build the metabolic foundation (lean muscle mass, improved hormonal milieu) that makes weight maintenance possible even after semaglutide is discontinued

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The use of recombinant human growth hormone to protect against muscle weakness in patients undergoing anterior cruciate ligament reconstruction: a pilot, randomized placebo-controlled trial

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