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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

doi: 10.47957/ijpda.v12i1.568 133

Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, et al

Ann Arbor: The University of Michigan Press

Hale, V

Statistical Methods The sample size calculations for the interventional cohort are based on unpublished data from Profil which evaluated total GSH measurement in healthy young subjects