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ATP7B is an essential Cu transporter that regulates Cu transport from the cytoplasm to the Golgi apparatus and lysosomes to maintain Cu homeostasis (Polishchuk et al., 2014)

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According to the World Health Organization, approximately 8%12% of reproductive-age couples experience fertility issues, with recent data indicating that infertility affects nearly 17.5% of adults globallyan alarming and escalating global health challenge ( The implications of fertility problems extend far beyond clinical diagnoses

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The Crem knockout ( Crem -/- ) mice, this upregulation is abolished in germ cells, while somatic expression of CYP51A1 remains unaffected

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