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Some facts on men and mice (for more details, please see Table 1 ): mice are 3000 smaller mice and humans diverted 75 million years ago (Waterston et al., 2002) laboratory mice are highly inbred their genome is approximately 14% smaller, probably due to deletions (Waterston et al., 2002) the DNA sequence identity is only 40% (Waterston et al., 2002) the average substitution rate in mice is twofold higher than in humans (Waterston et al., 2002) manipulations of their genome may induce mutations in their microsatellite sequences (Zuo et al., 2012

Building on this, the use of multi-platforms, as well as the addition cutting-edge technologies such as single-cell analysis could be instrumental

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References 1 AbdelhamidS